Preisträger Medizinische Grundlagenforschung 1988 – 2012

2012 Prof. Dr. H.C. Reinhardt DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
 
2011 Dr. Daniel N. Wilson Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition und
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites
 
2010 Prof. Dr. Veit Hornung RIG-I-dependent sensing of poly (dA:dT) through the induction of an RNA polymerase III- transcribed RNA intermediate.
 
2009 Prof. Dr. Norbert Hübner Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
 
2008 Prof. Dr. Bernhard Nieswandt An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice.
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation and thrombus formation in vitro and in vivo.
 
2007 PD Dr. Volker Heussler Manipulation of Host Hepatocytes by the Malaria parasite for Delivery into Liver Sinusoids.
 
2006 Dr. Ann-Kristin Müller Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.
 
2006 Prof. Dr. Ivan Dikic Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
 
2005 PD Dr. med. Karl Rudolph Telomere length is reset during early mammalian embryogenesis.
Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescene Signaling.
 
2004 Dr. Michael Zeisberg BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury.
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.
 
2004 Dr. Kirsten Lauber Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal.
 
2003 Prof. Dr. Christian Weber Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury.
JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes.
 
2002 Prof. Dr. Patrick Cramer Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution.
 
2001 PD Dr. Elke Roeb An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist.
 
2000 Dr. habil. Thomas Willnow An Endocytic Pathway for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3.
 
1999 Prof. Dr. Richard Kroczek CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
 
1999 PD Dr. Rita Gerardy-Schahn Die Bedeutung der Polysialinsäure für das Wachstum und Metastasierungsverhalten neuroendokriner und lymphoider Tumoren.
 
1999 PD Dr. Ortrud Steinlein A Potassium Channel Mutation in Neonatal Human Epilepsy.
 
1998 Dr. Stefan Offermanns Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency.
 
1997 Prof. Dr. Dr. Manfred W. Kiliman Mutations in the testis/liver isoform of the phosphoylase kinase γ subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans.
 
1996 Prof. Dr. Dietmar Vestweber The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
 
1995 Dr. Ludwig Thierfelder A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
 
1994 Prof. Dr. Martin Krönke Human 55-kDa receptor for tumor necrosis factor couples to signal transduction cascades.
 
1993 PD Dr. Peter Gierschik sozyme-selective stimulation of phospholipase C-β2 by G-protein βγ-subunits.
 
1992 PD Dr. Klaus Ley Endothelial, not hemodynamic differences are responsible for preferential leukocyte rolling in rat mesenteric venules.
 
1991 Prof. Dr. Stefan H. E. Kaufmann T-Cells against a bacterial heat shock protein recognize stressed macrophages.
 
1990 Prof. Dr. Bernhard Fleischer Stimulation von T-Lymphozyten durch mikrobielle Exotoxine:
Ein in der Evolution konservierter Mechanismus.
 
1989 Prof. Dr. Peter C. Weber
PD Dr. Sven Fischer
Dr. Clemens von Schacky
zelluläre Funktionen.
 
1988 Prof. Dr. Wolfram H. Gerlich
Dr. Klaus-Hinrich Heermann
Wege zu einem optimalen Impfstoff gegen Hepatitis-B-Viren.
 
1988 Prof. Dr. Karl-G. Dorst Entwicklung und Erprobung eines integrativen Behandlungsprogramms bei essentieller Hypertonie.

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Fünf Nobelpreise für GlaxoSmithKline-Forscher

Fünf Nobelpreise für GlaxoSmithKline-Forscher